DSP 数字空间多组学技术服务介绍
非因生物的Digital Spatial Profiler (DSP) 数字空间多组学分析技术是针对肿瘤免疫和肿瘤微环境高精度、多维度分析的新一代空间组学技术,可以在单张切片上(FFPE 或鲜冻)通过兴趣点选择(ROI),分析每个微环境微小区域内的多达570 重蛋白组或18,000 重全转录组的原位表达谱。
非因生物引入中国第一个DSP 技术平台,率先搭建起国内领先的空间多组学实验室,现拥有3台DSP 仪器同步运行,是目前国内最大的 DSP 技术服务平台,已为数百个项目提供优质的空间多组学服务,包括DSP 空间蛋白组、DSP-CTA 癌症空间转录组、以及DSP-WTA 空间全转录组分析服务。非因生物拥有大量项目开发经验,多仪器高效运行,专业的技术支持和强大的生信分析团队,为您的科研保驾护航。
非因生物DSP工作原理
非因生物DSP技术服务的应用场景
非因生物DSP技术服务特点与优势
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异质性解析:可通过功能性的区域分割对组织空间异质性进行解析。
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更大的检测范围:可对样本进行全转录组或 150 重蛋白組检测,实现最多重、最高灵敏度的检测。
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可靠的效果:DSP 具有无与伦比的可重复性和可扩展性,可增加多样本分析和队列研究结果的一致性。
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样本将不再受限:从石蜡切片 (FFPE)、冰冻切片(FF)、穿刺活检 (CNB) 以及组织芯片(TMA)均可获得经验证的可靠且稳定的结果。
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结构决定功能:全面解析不同区域、不同功能的细胞亚群或关键结构,构建生物学全貌。
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强大的数据综合分析及深度挖掘能力:完全标准化的集成生物信息学分析流程,经验丰富的多组学 数据分析团队,能够对生物学数据及临床数据进行综合分析及深度挖掘,使得论文发表更加便捷化、个性化。
该场景适用于以下应用方向
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蛋白功能分析
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细胞信号转导机理研究
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疾病模型分子机理挖掘与探索性研究
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蛋白功能分析
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细胞信号转导机理研究
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疾病模型分子机理挖掘与探索性研究
DSP技术平台应用文献总览
DSP技术平台应用代表性文献
参考文献
PMID | 文献名 | 发表期刊 | 影响因子 |
---|---|---|---|
31942071 | Tertiary lymphoid structures improve immunotherapy and survival in melanoma | Nature | 43.07 |
31942075 | B cells and tertiary lymphoid structures promote immunotherapy response | Nature | 43.07 |
33915569 | COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets. | Nature | 43.07 |
33780969 | The spatial landscape of lung pathology during COVID-19 progression | Nature | 42.778 |
32393914 | Multiplex Digital Spatial Profiling of Proteins and RNA in Fixed Tissue | Nature Biotechnology | 36.558 |
34798069 | Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb | Cell | 36.216 |
30297909 | Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma | Nature Medicine | 36.13 |
30297911 | Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma | Nature Medicine | 36.13 |
33495604 | Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma | Nat Med | 36.13 |
32976798 | Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma | Cell | 33.116 |
34450029 | Spatially organized multicellular immune hubs in human colorectal cancer | Cell | 33.116 |
31332390 | A case report of clonal EBV-like memory CD4+ T cell activation in fatal checkpoint inhibitor-induced encephalitis | Nature Medicine | 30.641 |
35618839 | Pembrolizumab in soft-tissue sarcomas with tertiary lymphoid structures: a phase 2 PEMBROSARC trial cohort | Nat Med | 30.641 |
35589854 | Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial | Nat Med | 30.641 |
34341583 | Spatial omics and multiplexed imaging to explore cancer biology | Nat Methods | 28.467 |
34479871 | Low Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy | Cancer Discov | 26.37 |
34642171 | Single-cell atlas of lineage states, tumor microenvironment and subtype-specific expression programs in gastric cancer | Cancer Discov | 26.37 |
34358448 | The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer | Cancer Cell | 23.916 |
34678153 | Expression of chimeric antigen receptor therapy targets detected by single-cell sequencing of normal cells may contribute to off-tumor toxicity | Cancer Cell | 23.916 |
34966897 | Spatial proteomic characterization of HER2-positive breast tumors through neoadjuvant therapy predicts response | Nature Cancer | 23.177 |
31350575 | Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer’s disease patient brain samples | Acta Neuropathol | 18.174 |
34376518 | Comparison between non-pulmonary and pulmonary immune responses in a HIV decedent who succumbed to COVID-19 | Gut | 17.943 |
33205067 | Elevated Serum Amino Acids Induce a Subpopulation of Alpha Cells to Initiate Pancreatic Neuroendocrine Tumor Formation | Cell Reports Medicine | 16.988 |
33778787 | Spatial mapping of SARS-CoV-2 and H1N1 Lung Injury Identifies Differential Transcriptional Signatures | Cell Reports Medicine | 16.988 |
35233546 | System-wide transcriptome damage and tissue identity loss in COVID-19 patients | Cell Rep Med | 16.988 |
32493790 | Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia | Science translational medicine | 16.89 |
33563664 | Non-genetic evolution drives lung adenocarcinoma spatial heterogeneity and progression | Cancer discovery | 15.929 |
33826920 | Applicability of spatial transcriptional profiling to cancer research | Mol Cell | 15.584 |
32375063 | Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36 | Neuron | 14.249 |
31039798 | The tech for the next decade: promises andchallenges in genome biology | Genome Biology | 14.028 |
35490853 | Discovery of Biomarkers of Resistance to Immune Checkpoint Blockade in NSCLC Using High-Plex Digital Spatial Profiling | J Thorac Oncol | 12.46 |
33298930 | Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection | Nat Commun | 12.298 |
33658518 | Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling | Nat Commun | 12.298 |
33712587 | Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions | Nat Commun | 12.298 |
34188042 | Resolution of tissue signatures of therapy response in patients with recurrent GBM treated with neoadjuvant anti-PD1 | Nat Commun | 11.878 |
34162872 | Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer | Developmental Therapeutics Branch, Center for Cancer Research | 11.878 |
34285220 | High-depth spatial transcriptome analysis by photo-isolation chemistry | Nat Commun | 11.878 |
35046414 | Advances in mixed cell deconvolution enable quantification of cell types in spatial transcriptomic data | Nat Commun | 11.878 |
35022412 | Postmortem high-dimensional immune profiling of severe COVID-19 patients reveals distinct patterns of immunosuppression and immunoactivation | 11.878 | |
35418199 | Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer | Nat Commun | 11.878 |
34675048 | Profiling of lung SARS-CoV-2 and influenza virus infection dissects virus-specific host responses and gene signatures | Eur Respir J | 11.807 |
34271973 | Single-cell and spatial analyses of cancer cells: toward elucidating the molecular mechanisms of clonal evolution and drug resistance acquisition | Inflamm Regen | 10.426 |
33262254 | Comprehensive analysis of cutaneous and uveal melanoma liver metastases. | J Immunother Cancer | 10.252 |
29784033 | AGBT meeting report | Genome Biol. | 10.124 |
32253229 | Biomarkers Associated With Beneficial PD-1 Checkpoint Blockade in Non-Small Cell Lung Cancer (NSCLC) Identified Using High-Plex Digital Spatial Profiling | Clinical Cancer Research | 10.107 |
32299817 | Multiplexed Evaluation of Microdosed Antineoplastic Agents In Situ in the Tumor Microenvironment of Patients With Soft Tissue Sarcoma | Clinical Cancer Research | 10.107 |
32377572 | Multiplex bioimaging of single-cell spatial profiles for precision cancer diagnostics and therapeutics | Npj Precision Oncology | 10.092 |
34050252 | Models that combine transcriptomic with spatial protein information exceed the predictive value for either single modality | NPJ Precis Oncol | 10.092 |
34667258 | Multiomics analysis of serial PARP inhibitor treated metastatic TNBC inform on rational combination therapies | NPJ Precis Oncol | 10.092 |
32414858 | The Society for Immunotherapy of Cancer statement on best practices for multiplex immunohistochemistry (IHC) and immunofluorescence (IF) staining and validation. | Journal for ImmunoTherapy of Cancer | 9.913 |
35508175 | ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancer | Dev Cell | 9.19 |
29903534 | Harnessing tumor evolution to circumvent resistance | Trends Genet. | 9.012 |
31189645 | High-plex predictive marker discovery for melanoma immunotherapy treated patients using Digital Spatial Profiling | Clinical Cancer Research | 8.911 |
31948941 | Linking transcriptomic and imaging data defines features of a favorable tumor immune microenvironment (TIME) and identifies a combination biomarker for primary melanoma | Cancer Research | 8.911 |
33257424 | Early Adaptation of Colorectal Cancer Cells to the Peritoneal Cavity Is Associated with Activation of "Stemness" Programs and Local Inflammation | Clin Cancer Res | 8.911 |
34465600 | Alpha-smooth muscle actin expression in the stroma predicts resistance to trastuzumab in patients with early-stage HER2-positive breast cancer | Clin Cancer Res | 8.911 |
35031546 | Metabolic Alterations and WNT Signaling Impact Immune Response in HGSOC | Clin Cancer Res . | 8.911 |
35262677 | Immunostimulatory Cancer-Associated Fibroblast Subpopulations Can Predict Immunotherapy Response in Head and Neck Cancer | Clin Cancer Res | 8.911 |
35617517 | Spatial and Transcriptomic Analysis of Perineural Invasion in Oral Cancer | Clin Cancer Res | 8.911 |
35511927 | CXCL14 Promotes a Robust Brain Tumor-Associated Immune Response in Glioma | Clin Cancer Res | 8.911 |
35527216 | Spatial determinants of CD8 + T cell differentiation in cancer | Trends Cancer | 8.884 |
35378331 | The Host-Microbiome Response to Hyperbaric Oxygen Therapy in Ulcerative Colitis Patients | Cell Mol Gastroenterol Hepatol | 8.797 |
31703602 | Distinct tumor microenvironments of lytic and blastic bone metastases in prostate cancer patients | Journal for ImmunoTherapy of Cancer | 8.676 |
32581061 | High Dose-Rate Brachytherapy of Localized Prostate Cancer Converts Tumors From Cold to Hot | Journal for ImmunoTherapy of Cancer | 8.676 |
34725212 | Synergistic antitumor activity of pan-PI3K inhibition and immune checkpoint blockade in bladder cancer | J Immunother Cancer | 8.676 |
35264439 | Spatial profiling reveals association between WNT pathway activation and T-cell exclusion in acquired resistance of synovial sarcoma to NY-ESO-1 transgenic T-cell therapy | J Immunother Cancer | 8.676 |
35618288 | Spatial transcriptomics of macrophage infiltration in non-small cell lung cancer reveals determinants of sensitivity and resistance to anti-PD1/PD-L1 antibodies | J Immunother Cancer | 8.676 |
34341074 | Predicting molecular phenotypes from histopathology images: a transcriptome-wide expression-morphology analysis in breast cancer | Cancer Res | 8.378 |
34555393 | The spatially resolved transcriptional profile of acute T-cell mediated rejection in a kidney allograft | Kidney Int | 8.306 |
35227689 | Digital Spatial Profiling of Collapsing Glomerulopathy | Kidney Int | 8.306 |
35461615 | Virus-related collapsing glomerulopathy, a common mechanism of injury? | Kidney Int | 8.306 |
34928497 | 5-alpha reductase inhibitors induce a prostate luminal to club cell transition in human benign prostatic hyperplasia | The Journal of pathology | 7.996 |
34818552 | Immuno-transcriptomic profiling of extracranial pediatric solid malignancies | Cell Rep | 7.815 |
35740993 | Lung Spatial Profiling Reveals a T Cell Signature in COPD Patients with Fatal SARS-CoV-2 Infection | Cells | 7.666 |
32267932 | LAG3: A novel immune checkpoint expressed by multiple lymphocyte subsets in diffuse large B-cell lymphoma | Blood Advances | 7.637 |
35164877 | Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling | Acta Neuropathol Commun | 7.578 |
35309370 | Digital Spatial Profiling of Individual Glomeruli From Patients With Anti-Neutrophil Cytoplasmic Autoantibody-Associated Glomerulonephritis | Front Immunol | 7.561 |
34406120 | Innate immune activation by checkpoint inhibition in human patient-derived lung cancer tissues | Elife | 7.551 |
31432604 | Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease | Aging Cell | 7.238 |
34726836 | Novel intragraft regulatory lymphoid structures in kidney allograft tolerance | Am J Transplant | 7.163 |
34820878 | Spatial molecular profiling of a central nervous system low-grade diffusely infiltrative tumour with INI1 deficiency (CNS LGDIT-INI1) featuring a high-grade AT/RT component | Neuropathol Appl Neurobiol | 6.878 |
34673228 | High-plex expression profiling reveals that implants drive spatiotemporal protein production and innate immune activation for tissue repair | Acta Biomater | 6.638 |
35091681 | Loss of NFE2L3 protects against inflammation-induced colorectal cancer through modulation of the tumor microenvironment | Oncogene | 6.634 |
33402537 | Hyaluronidase Impairs Neutrophil Function and Promotes Group B Streptococcus Invasion and Preterm Labor in Nonhuman Primates | mBio | 6.63 |
33348809 | Murine-and Human-Derived Autologous Organoid/Immune Cell Co-Cultures as Pre-Clinical Models of Pancreatic Ductal Adenocarcinoma | Cancers (Basel) | 6.575 |
34944780 | Disruption of Her2-Induced PD-L1 Inhibits Tumor Cell Immune Evasion in Patient-Derived Gastric Cancer Organoids | Cancers (Basel) | 6.575 |
35158790 | NanoString Digital Molecular Profiling of Protein and microRNA in Rhabdomyosarcoma | Cancers (Basel) | 6.575 |
35454904 | Dissecting Tumor-Immune Microenvironment in Breast Cancer at a Spatial and Multiplex Resolution | Cancers (Basel) | 6.575 |
35454766 | Cutting-Edge Platforms for Analysis of Immune Cells in the Hepatic Microenvironment—Focus on Tumor-Associated Macrophages in Hepatocellular Carcinoma | Cancers (Basel) | 6.575 |
Mapping Gene Expression in the Spatial Dimension | Neuroimage | 6.552 | |
34126195 | Hedgehog transcriptional effector GLI mediates mTOR-Induced PD-L1 expression in gastric cancer organoids | Cancer Lett | 6.508 |
33072322 | Immune contexture analysis in immuno‐oncology: applications and challenges of multiplex fluorescent immunohistochemistry | Clin Transl Immunology. | 6.484 |
31654804 | Identification of non-cancer cells from cancer transcriptomic data | Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms | 6.304 |
34699906 | High-plex spatial RNA profiling reveals cell type-specific biomarker expression during melanoma development | J Invest Dermatol | 6.29 |
31672982 | Single cell analysis to dissect molecular heterogeneity and disease evolution in metastatic melanoma | Cell Death Dis. | 6.28 |
33261133 | High-Plex and High-Throughput Digital Spatial Profiling of Non-Small-Cell Lung Cancer (NSCLC) | Cancers | 6.126 |
33228231 | Immunoprofiling in Neuroendocrine Neoplasms Unveil Immunosuppressive Microenvironment | Cancers | 6.126 |
A High-Dimensional Window into the Micro-Environment of Triple Negative Breast Cancer | Cancers | 6.126 | |
34503266 | Best Practices for Spatial Profiling for Breast Cancer Research with the GeoMx® Digital Spatial Profiler | Cancers | 6.126 |
34778231 | Tumor Microenvironment Profiles Reveal Distinct Therapy-Oriented Proteogenomic Characteristics in Colorectal Cancer | Front Bioeng Biotechnol | 6.064 |
31830001 | Immunologic alterations in the pancreatic cancer microenvironment of patients treated with neoadjuvant chemotherapy and radiotherapy | JCI Insight | 6.014 |
31960425 | Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development. | J Pathol | 5.979 |
34018684 | Multiplexed digital spatial profiling of invasive breast tumors from Black and White women. | Mol Oncol | 5.962 |
30570141 | New tools for pathology: a user's review of a highly multiplexed method for in situ analysis of protein and RNA expression in tissue | Journal of Pathology | 5.942 |
34580877 | Stroma Areactive Invasion Front Areas (SARIFA) - a new prognostic biomarker in gastric cancer related to tumor-promoting adipocytes | J Pathol | 5.942 |
35365599 | Clinical and translational values of spatial transcriptomics | Signal Transduct Target Ther | 5.873 |
32751181 | Personal Medicine and Bone Metastases: Biomarkers, Micro-RNAs and Bone Metastases | Cancers | 5.744 |
32917035 | Transcriptional Spatial Profiling of Cancer Tissues in the Era of Immunotherapy: The Potential and Promise | Cancers | 5.744 |
33096480 | Intra-tumour heterogeneity of diffuse large B-cell lymphoma involves the induction of diversified stroma-tumour interfaces | EBioMedicine | 5.736 |
33434721 | Spatially resolved transcriptomics and its applications in cancer | Current Opinion in Genetics & Development | 5.517 |
35063125 | The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2 | Stem Cell Reports | 5.499 |
32814992 | Dissecting the immune landscape of tumor draining lymph nodes in melanoma with high-plex spatially resolved protein detection | Cancer Immunology, Immunotherapy | 5.442 |
35154906 | T-SIGn tumor reengineering therapy and CAR T cells synergize in combination therapy to clear human lung tumor xenografts and lung metastases in NSG mice | Oncoimmunology | 5.333 |
35465329 | Digital Spatial Profiling Reveals Functional Shift of Enterochromaffin Cell in Patients With Ulcerative Colitis | Front Cell Dev Biol | 5.206 |
33584676 | Next Generation Imaging Techniques to Define Immune Topographies in Solid Tumors | Frontiers in Immunology | 5.085 |
32328458 | Changing Technologies of RNA Sequencing and Their Applications in Clinical Oncology | Frontiers in oncology | 4.848 |
32793500 | Unraveling the Complexity of the Cancer Microenvironment With Multidimensional Genomic and Cytometric Technologies | Frontiers in Oncology | 4.848 |
33542903 | Highly Multiplexed Digital Spatial Profiling of the Tumor Microenvironment of Head and Neck Squamous Cell Carcinoma Patients | Frontiers in Oncology | 4.848 |
33841448 | Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When? | Front Immunol | 4.716 |
35651606 | Dissecting Tissue Compartment-Specific Protein Signatures in Primary and Metastatic Oropharyngeal Squamous Cell Carcinomas | Front Immunol. | 4.716 |
35554927 | Spatial transcriptome of a germinal center plasmablastic burst hints at MYD88/CD79B mutants-enriched diffuse large B-cell lymphomas | Eur J Immunol | 4.695 |
34304051 | The Pandora’s box of novel technologies that may revolutionize lung cancer | Lung Cancer | 4.599 |
32249818 | Digital Quantitative Assessment of PD-L1 Using Digital Spatial Profiling | Laboratory Investigation | 4.197 |
33623115 | Protein-based immune profiles of basal-like vs. luminal breast cancers | Laboratory investigation | 4.197 |
The Potential of OMICs Technologies for the Treatment of Immune-Mediated Inflammatory Diseases | Int J Mol Sci | 4.183 | |
33097816 | From whole-mount to single-cell spatial assessment of gene expression in 3D | Commun Biol | 4.165 |
33335270 | Molecularly targeted photothermal ablation improves tumor specificity and immune modulation in a rat model of hepatocellular carcinoma | Communications Biology | 4.165 |
33854972 | Multiplexed Immunohistochemistry and Digital Pathology as the Foundation for Next-Generation Pathology in Melanoma: Methodological Comparison and Future Clinical Applications. | Front Oncol | 4.137 |
34123788 | Cutaneous Melanoma Classification: The Importance of High-Throughput Genomic Technologies | Front Oncol | 4.137 |
35083152 | Spatial Profiling Identifies Prognostic Features of Response to Adjuvant Therapy in Triple Negative Breast Cancer (TNBC) | Front Oncol | 4.137 |
34838031 | The tumor immune microenvironment of primary and metastatic HER2- positive breast cancers utilizing gene expression and spatial proteomic profiling | J Transl Med | 4.098 |
34838031 | The tumor immune microenvironment of primary and metastatic HER2- positive breast cancers utilizing gene expression and spatial proteomic profiling | J Transl Med | 4.098 |
34561502 | Dissection of the bone marrow microenvironment in hairy cell leukaemia identifies prognostic tumour and immune related biomarkers | Sci Rep | 4.011 |
32313087 | Spatially-resolved quantification of proteins in triple negative breast cancers reveals differences in the immune microenvironment associated with prognosis. | Scientific Reports | 3.998 |
32339226 | Cell Atlas technologies and insights into tissue architecture | Biochemical Journal | 3.995 |
OMICs, Epigenetics, and Genome Editing Techniques for Food and Nutritional Security | Plants | 3.935 | |
33005195 | Identification of Molecular Signatures in Neural Differentiation and Neurological Diseases Using Digital Color-Coded Molecular Barcoding | Stem Cells International | 3.869 |
33611828 | Single-cell sequencing in translational cancer research and challenges to meet clinical diagnostic needs | Genes Chromosomes Cancer | 3.836 |
35672770 | Digital quantification of p16-positive foci in fibrotic interstitial lung disease is associated with a phenotype of idiopathic pulmonary fibrosis with reduced survival | Respir Res | 3.829 |
32765578 | Unraveling Heterogeneity in Transcriptome and Its Regulation Through Single-Cell Multi-Omics Technologies | Frontiers in Genetics | 3.819 |
34506752 | Molecular Profiling of Coronavirus Disease 2019 (COVID-19) Autopsies Uncovers Novel Disease Mechanisms | Am J Pathol | 3.762 |
Next-Generation Digital Histopathology of the Tumor Microenvironment | Genes | 3.759 | |
34366832 | Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study | Front Aging Neurosci | 3.633 |
30038466 | Multiparametric analysis of colorectal cancer immune responses | World J Gastroenterol | 3.602 |
34386519 | Tissue Multiplex Analyte Detection in Anatomic Pathology – Pathways to Clinical Implementation | Front Mol Biosci | 3.565 |
34125481 | Spatial transcriptomics and proteomics technologies for deconvoluting the tumor microenvironment | Biotechnol J | 3.543 |
35111697 | Elucidating Spatially-Resolved Changes in Host Signaling During Plasmodium Liver-Stage Infection | Front Cell Infect Microbiol | 3.518 |
Clinical and research applications of multiplexed immunohistochemistry and in situ hybridization | The Journal of Pathology | 3.489 | |
34681023 | High-Dimensional Single-Cell Transcriptomics in Melanoma and Cancer Immunotherapy | Genes (Basel) | 3.331 |
32549391 | Resolving Metabolic Heterogeneity in Experimental Models of the Tumor Microenvironment from a Stable Isotope Resolved Metabolomics Perspective | metabolites | 3.303 |
35428170 | Identification and prognostic analysis of biomarkers to predict the progression of pancreatic cancer patients | Mol Med | 2.991 |
32458049 | Digital Spatial Profiling Application in Breast Cancer: A User's Perspective | Virchows Archiv | 2.906 |
34529723 | Cracking it - successful mRNA extraction for digital gene expression analysis from decalcified, formalin-fixed and paraffin-embedded bone tissue | PLoS One | 2.776 |
35580406 | Placental interferon signaling is involved in chronic intervillositis of unknown etiology | Placenta | 2.773 |
34782601 | From bulk, single-cell to spatial RNA sequencing | Int J Oral Sci | 2.75 |
31895753 | Phase Ib/II trial testing combined radiofrequency ablation and ipilimumab in uveal melanoma (SECIRA-UM) | Melanoma Research | 2.381 |
31079803 | Future Research Goals in Immunotherapy | Surgical Oncology Clinics of North America | 2.34 |
33709779 | Molecular and morphological changes induced by ivosidenib correlate with efficacy in mutant- IDH1 cholangiocarcinoma | Future Oncol | 2.332 |
Advanced molecular characterization using Digital Spatial Profiling Technology on immuno-oncology targets in methylated compared with unmethylated IDH-wildtype glioblastoma. | Journal of Oncology | 2.096 | |
33857852 | Molecular risk markers related to local tumor recurrence at histological margin-free endoscopically resected early gastric cancers: A pilot study | Pathol Res Pract | 2.05 |
34590593 | New Insights into the Biology and Diagnosis of Splenic Marginal Zone Lymphomas | Curr Oncol | 1.862 |
33692852 | Integrin-linked kinase pathway in heterogeneous pulmonary sarcomatoid carcinoma | Oncology letters | 0.987 |
High multiplex, digital spatial profiling of proteins and RNA in fixed tissue using genomic detection methods | bioRxiv | ||
Defining the microenvironment landscape of bladder cancer using highly multiplexed spatial genomic and proteomic analysis | bioRxiv | ||
Single-nucleus and spatial transcriptomics of archival pancreatic cancer reveals multi-compartment reprogramming after neoadjuvant treatment | bioRxiv | ||
33083730 | A Spatially Resolved Dark- versus Light-Zone Microenvironment Signature Subdivides Germinal Center-Related Aggressive B Cell Lymphomas | iScience | |
Transcriptome-wide spatial RNA profiling maps the cellular architecture of the developing human neocortex | bioRxiv | ||
34162701 | A Distinct Innate Immune Signature of Early Onset Colorectal Cancer | Immunohorizons | |
32215866 | New Technologies to Image Tumors | Cancer Treat Res | |
Whole Slide Imaging and Research Applications | Whole Slide Imaging | ||
34750164 | Genome analysis identifies differences in the transcriptional targets of duodenal versus pancreatic neuroendocrine tumours | BMJ Open Gastroenterol | |
An Investigation of Attention Mechanisms in Histopathology Whole-Slide-Image Analysis for Regression Objectives | IEEE/CVF | ||
34890147 | Mixed Effects Machine Learning Models for Colon Cancer Metastasis Prediction using Spatially Localized Immuno-Oncology Markers | Pac Symp Biocomput | |
35580295 | Protein Profiling of Breast Cancer for Treatment Decision-Making | Am Soc Clin Oncol Educ Book | |
35751462 | The Role of Nerve Fibers in the Tumor Immune Microenvironment of Solid Tumors | Adv Biol (Weinh) | |
30613381 | Dissecting diffuse large B-cell lymphomas of the “not otherwise specified” type: the impact of molecular techniques | F1000research | |
A user's perspective on GeoMx digital spatial profiling | Immuno-Oncology Technology | ||
High multiplex analysis of the immune microenvironment in bone marrow trephine samples using GeoMX™ digital spatial profiling | Immuno-Oncology Technology | ||
31502169 | High-Plex Spatially Resolved RNA and Protein Detection Using Digital Spatial Profiling: A Technology Designed for Immuno-oncology Biomarker Discovery and Translational Research | Biomarkers for Immunotherapy of Cancer | |
32394392 | GeoMx™ RNA Assay: High Multiplex, Digital, Spatial Analysis of RNA in FFPE Tissue | Methods in Molecular Biology | |
31502165 | Overview of Tissue Imaging Methods. | Biomarkers for Immunotherapy of Cancer | |
Spatially-resolved proteomics and transcriptomics: An emerging digital spatial profiling approach for tumor microenvironment | Visualized Cancer Medicine | ||
35194605 | A model of persistent post SARS-CoV-2 induced lung disease for target identification and testing of therapeutic strategies | bioRxiv |