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反相蛋白组学 技术服务

中国第一个DSP空间多组学技术平台

DSP 数字空间多组学技术服务介绍

非因生物的Digital Spatial Profiler (DSP) 数字空间多组学分析技术是针对肿瘤免疫和肿瘤微环境高精度、多维度分析的新一代空间组学技术,可以在单张切片上(FFPE 或鲜冻)通过兴趣点选择(ROI),分析每个微环境微小区域内的多达570 重蛋白组或18,000 重全转录组的原位表达谱。

非因生物引入中国第一个DSP 技术平台,率先搭建起国内领先的空间多组学实验室,现拥有3台DSP 仪器同步运行,是目前国内最大的 DSP 技术服务平台,已为数百个项目提供优质的空间多组学服务,包括DSP 空间蛋白组、DSP-CTA 癌症空间转录组、以及DSP-WTA 空间全转录组分析服务。非因生物拥有大量项目开发经验,多仪器高效运行,专业的技术支持和强大的生信分析团队,为您的科研保驾护航。 

非因生物DSP工作原理

非因生物DSP 技术服务内容

非因生物DSP技术服务的应用场景

非因生物DSP技术服务特点与优势

  • 异质性解析:可通过功能性的区域分割对组织空间异质性进行解析。
  • 更大的检测范围:可对样本进行全转录组或 150 重蛋白組检测,实现最多重、最高灵敏度的检测。
  • 可靠的效果:DSP 具有无与伦比的可重复性和可扩展性,可增加多样本分析和队列研究结果的一致性。
  • 样本将不再受限:从石蜡切片 (FFPE)、冰冻切片(FF)、穿刺活检 (CNB) 以及组织芯片(TMA)均可获得经验证的可靠且稳定的结果。
  • 结构决定功能:全面解析不同区域、不同功能的细胞亚群或关键结构,构建生物学全貌。
  • 强大的数据综合分析及深度挖掘能力:完全标准化的集成生物信息学分析流程,经验丰富的多组学 数据分析团队,能够对生物学数据及临床数据进行综合分析及深度挖掘,使得论文发表更加便捷化、个性化。

该场景适用于以下应用方向

  • 蛋白功能分析
  • 细胞信号转导机理研究
  • 疾病模型分子机理挖掘与探索性研究
  • 蛋白功能分析
  • 细胞信号转导机理研究
  • 疾病模型分子机理挖掘与探索性研究

DSP技术平台应用文献总览

DSP技术平台应用代表性文献

参考文献

PMID文献名发表期刊影响因子
31942071Tertiary lymphoid structures improve immunotherapy and survival in melanomaNature43.07
31942075B cells and tertiary lymphoid structures promote immunotherapy responseNature43.07
33915569COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets.Nature43.07
33780969The spatial landscape of lung pathology during COVID-19 progressionNature42.778
32393914Multiplex Digital Spatial Profiling of Proteins and RNA in Fixed Tissue Nature Biotechnology36.558
34798069Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulbCell36.216
30297909Neoadjuvant immune checkpoint blockade in high-risk resectable melanomaNature Medicine36.13
30297911Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanomaNature Medicine36.13
33495604Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcomaNat Med36.13
32976798Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular CarcinomaCell33.116
34450029Spatially organized multicellular immune hubs in human colorectal cancerCell33.116
31332390A case report of clonal EBV-like memory CD4+ T cell activation in fatal checkpoint inhibitor-induced encephalitisNature Medicine30.641
35618839Pembrolizumab in soft-tissue sarcomas with tertiary lymphoid structures: a phase 2 PEMBROSARC trial cohortNat Med30.641
35589854Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trialNat Med30.641
34341583Spatial omics and multiplexed imaging to explore cancer biologyNat Methods28.467
34479871Low Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to ImmunotherapyCancer Discov26.37
34642171Single-cell atlas of lineage states, tumor microenvironment and subtype-specific expression programs in gastric cancerCancer Discov26.37
34358448The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancerCancer Cell23.916
34678153Expression of chimeric antigen receptor therapy targets detected by single-cell sequencing of normal cells may contribute to off-tumor toxicityCancer Cell23.916
34966897Spatial proteomic characterization of HER2-positive breast tumors through neoadjuvant therapy predicts responseNature Cancer23.177
31350575Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer’s disease patient brain samplesActa Neuropathol18.174
34376518Comparison between non-pulmonary and pulmonary immune responses in a HIV decedent who succumbed to COVID-19Gut17.943
33205067Elevated Serum Amino Acids Induce a Subpopulation of Alpha Cells to Initiate Pancreatic Neuroendocrine Tumor FormationCell Reports Medicine16.988
33778787Spatial mapping of SARS-CoV-2 and H1N1 Lung Injury Identifies Differential Transcriptional SignaturesCell Reports Medicine16.988
35233546System-wide transcriptome damage and tissue identity loss in COVID-19 patientsCell Rep Med16.988
32493790Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemiaScience translational medicine16.89
33563664Non-genetic evolution drives lung adenocarcinoma spatial heterogeneity and progressionCancer discovery15.929
33826920Applicability of spatial transcriptional profiling to cancer researchMol Cell15.584
32375063Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36Neuron14.249
31039798The tech for the next decade: promises andchallenges in genome biologyGenome Biology14.028
35490853Discovery of Biomarkers of Resistance to Immune Checkpoint Blockade in NSCLC Using High-Plex Digital Spatial ProfilingJ Thorac Oncol12.46
33298930Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infectionNat Commun12.298
33658518Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profilingNat Commun12.298
33712587Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactionsNat Commun12.298
34188042Resolution of tissue signatures of therapy response in patients with recurrent GBM treated with neoadjuvant anti-PD1Nat Commun11.878
34162872Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancerDevelopmental Therapeutics Branch, Center for Cancer Research11.878
34285220High-depth spatial transcriptome analysis by photo-isolation chemistryNat Commun11.878
35046414Advances in mixed cell deconvolution enable quantification of cell types in spatial transcriptomic dataNat Commun11.878
35022412Postmortem high-dimensional immune profiling of severe COVID-19 patients reveals distinct patterns of immunosuppression and immunoactivation11.878
35418199Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancerNat Commun11.878
34675048Profiling of lung SARS-CoV-2 and influenza virus infection dissects virus-specific host responses and gene signaturesEur Respir J11.807
34271973Single-cell and spatial analyses of cancer cells: toward elucidating the molecular mechanisms of clonal evolution and drug resistance acquisitionInflamm Regen10.426
33262254Comprehensive analysis of cutaneous and uveal melanoma liver metastases.J Immunother Cancer10.252
29784033AGBT meeting reportGenome Biol.10.124
32253229Biomarkers Associated With Beneficial PD-1 Checkpoint Blockade in Non-Small Cell Lung Cancer (NSCLC) Identified Using High-Plex Digital Spatial Profiling Clinical Cancer Research10.107
32299817Multiplexed Evaluation of Microdosed Antineoplastic Agents In Situ in the Tumor Microenvironment of Patients With Soft Tissue Sarcoma Clinical Cancer Research10.107
32377572Multiplex bioimaging of single-cell spatial profiles for precision cancer diagnostics and therapeuticsNpj Precision Oncology10.092
34050252Models that combine transcriptomic with spatial protein information exceed the predictive value for either single modalityNPJ Precis Oncol10.092
34667258Multiomics analysis of serial PARP inhibitor treated metastatic TNBC inform on rational combination therapiesNPJ Precis Oncol10.092
32414858The Society for Immunotherapy of Cancer statement on best practices for multiplex immunohistochemistry (IHC) and immunofluorescence (IF) staining and validation.Journal for ImmunoTherapy of Cancer9.913
35508175ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancerDev Cell9.19
29903534Harnessing tumor evolution to circumvent resistanceTrends Genet.9.012
31189645High-plex predictive marker discovery for melanoma immunotherapy treated patients using Digital Spatial ProfilingClinical Cancer Research8.911
31948941Linking transcriptomic and imaging data defines features of a favorable tumor immune microenvironment (TIME) and identifies a combination biomarker for primary melanomaCancer Research8.911
33257424Early Adaptation of Colorectal Cancer Cells to the Peritoneal Cavity Is Associated with Activation of "Stemness" Programs and Local InflammationClin Cancer Res8.911
34465600Alpha-smooth muscle actin expression in the stroma predicts resistance to trastuzumab in patients with early-stage HER2-positive breast cancerClin Cancer Res8.911
35031546Metabolic Alterations and WNT Signaling Impact Immune Response in HGSOCClin Cancer Res
.
8.911
35262677Immunostimulatory Cancer-Associated Fibroblast Subpopulations Can Predict Immunotherapy Response in Head and Neck CancerClin Cancer Res8.911
35617517Spatial and Transcriptomic Analysis of Perineural Invasion in Oral CancerClin Cancer Res8.911
35511927CXCL14 Promotes a Robust Brain Tumor-Associated Immune Response in GliomaClin Cancer Res8.911
35527216Spatial determinants of CD8 + T cell differentiation in cancerTrends Cancer8.884
35378331The Host-Microbiome Response to Hyperbaric Oxygen Therapy in Ulcerative Colitis PatientsCell Mol Gastroenterol Hepatol8.797
31703602Distinct tumor microenvironments of lytic and blastic bone metastases in prostate cancer patientsJournal for ImmunoTherapy of Cancer8.676
32581061High Dose-Rate Brachytherapy of Localized Prostate Cancer Converts Tumors From Cold to Hot Journal for ImmunoTherapy of Cancer8.676
34725212Synergistic antitumor activity of pan-PI3K inhibition and immune checkpoint blockade in bladder cancerJ Immunother Cancer8.676
35264439Spatial profiling reveals association between WNT pathway activation and T-cell exclusion in acquired resistance of synovial sarcoma to NY-ESO-1 transgenic T-cell therapyJ Immunother Cancer8.676
35618288Spatial transcriptomics of macrophage infiltration in non-small cell lung cancer reveals determinants of sensitivity and resistance to anti-PD1/PD-L1 antibodiesJ Immunother Cancer8.676
34341074Predicting molecular phenotypes from histopathology images: a transcriptome-wide expression-morphology analysis in breast cancerCancer Res8.378
34555393The spatially resolved transcriptional profile of acute T-cell mediated rejection in a kidney allograftKidney Int8.306
35227689Digital Spatial Profiling of Collapsing GlomerulopathyKidney Int8.306
35461615Virus-related collapsing glomerulopathy, a common mechanism of injury?Kidney Int8.306
349284975-alpha reductase inhibitors induce a prostate luminal to club cell transition in human benign prostatic hyperplasiaThe Journal of pathology7.996
34818552Immuno-transcriptomic profiling of extracranial pediatric solid malignanciesCell Rep7.815
 35740993Lung Spatial Profiling Reveals a T Cell Signature in COPD Patients with Fatal SARS-CoV-2 InfectionCells7.666
32267932LAG3: A novel immune checkpoint expressed by multiple lymphocyte subsets in diffuse large B-cell lymphomaBlood Advances7.637
35164877Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profilingActa Neuropathol Commun7.578
35309370Digital Spatial Profiling of Individual Glomeruli From Patients With Anti-Neutrophil Cytoplasmic Autoantibody-Associated GlomerulonephritisFront Immunol7.561
34406120Innate immune activation by checkpoint inhibition in human patient-derived lung cancer tissuesElife7.551
31432604Oxidative stress in the aging substantia nigra and the etiology of Parkinson's diseaseAging Cell7.238
34726836Novel intragraft regulatory lymphoid structures in kidney allograft toleranceAm J Transplant7.163
34820878Spatial molecular profiling of a central nervous system low-grade diffusely infiltrative tumour with INI1 deficiency (CNS LGDIT-INI1) featuring a high-grade AT/RT componentNeuropathol Appl Neurobiol6.878
34673228High-plex expression profiling reveals that implants drive spatiotemporal protein production and innate immune activation for tissue repairActa Biomater6.638
35091681Loss of NFE2L3 protects against inflammation-induced colorectal cancer through modulation of the tumor microenvironmentOncogene6.634
33402537Hyaluronidase Impairs Neutrophil Function and Promotes Group B Streptococcus Invasion and Preterm Labor in Nonhuman PrimatesmBio6.63
33348809Murine-and Human-Derived Autologous Organoid/Immune Cell Co-Cultures as Pre-Clinical Models of Pancreatic Ductal AdenocarcinomaCancers (Basel) 6.575
34944780Disruption of Her2-Induced PD-L1 Inhibits Tumor Cell Immune Evasion in Patient-Derived Gastric Cancer OrganoidsCancers (Basel)6.575
35158790NanoString Digital Molecular Profiling of Protein and microRNA in RhabdomyosarcomaCancers (Basel)6.575
35454904Dissecting Tumor-Immune Microenvironment in Breast Cancer at a Spatial and Multiplex ResolutionCancers (Basel)6.575
35454766Cutting-Edge Platforms for Analysis of Immune Cells in the Hepatic Microenvironment—Focus on Tumor-Associated Macrophages in Hepatocellular CarcinomaCancers (Basel)6.575
Mapping Gene Expression in the Spatial DimensionNeuroimage6.552
34126195Hedgehog transcriptional effector GLI mediates mTOR-Induced PD-L1 expression in gastric cancer organoidsCancer Lett6.508
33072322Immune contexture analysis in immuno‐oncology: applications and challenges of multiplex fluorescent immunohistochemistryClin Transl Immunology.6.484
31654804Identification of non-cancer cells from cancer transcriptomic dataBiochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms6.304
34699906High-plex spatial RNA profiling reveals cell type-specific biomarker expression during melanoma developmentJ Invest Dermatol6.29
31672982Single cell analysis to dissect molecular heterogeneity and disease evolution in metastatic melanomaCell Death Dis.6.28
33261133High-Plex and High-Throughput Digital Spatial Profiling of Non-Small-Cell Lung Cancer (NSCLC)Cancers6.126
33228231Immunoprofiling in Neuroendocrine Neoplasms Unveil Immunosuppressive MicroenvironmentCancers6.126
A High-Dimensional Window into the Micro-Environment of Triple Negative Breast CancerCancers6.126
34503266Best Practices for Spatial Profiling for Breast Cancer Research with the GeoMx® Digital Spatial ProfilerCancers6.126
34778231Tumor Microenvironment Profiles Reveal Distinct Therapy-Oriented Proteogenomic Characteristics in Colorectal CancerFront Bioeng Biotechnol6.064
31830001Immunologic alterations in the pancreatic cancer microenvironment of patients treated
with neoadjuvant chemotherapy and
radiotherapy
JCI Insight6.014
31960425Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development.J Pathol5.979
34018684Multiplexed digital spatial profiling of invasive breast tumors from Black and White women.Mol Oncol5.962
30570141 New tools for pathology: a user's review of a highly multiplexed method for in situ analysis of protein and RNA expression in tissueJournal of Pathology5.942
34580877Stroma Areactive Invasion Front Areas (SARIFA) - a new prognostic biomarker in gastric cancer related to tumor-promoting adipocytesJ Pathol5.942
35365599Clinical and translational values of spatial transcriptomicsSignal Transduct Target Ther5.873
32751181Personal Medicine and Bone Metastases: Biomarkers, Micro-RNAs and Bone MetastasesCancers5.744
32917035Transcriptional Spatial Profiling of Cancer Tissues in the Era of Immunotherapy: The Potential and PromiseCancers5.744
33096480Intra-tumour heterogeneity of diffuse large B-cell lymphoma involves the induction of diversified stroma-tumour interfacesEBioMedicine5.736
33434721Spatially resolved transcriptomics and its applications in cancer Current Opinion in Genetics & Development5.517
35063125The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2Stem Cell Reports5.499
32814992Dissecting the immune landscape of tumor draining lymph nodes in melanoma with high-plex spatially resolved protein detectionCancer Immunology, Immunotherapy5.442
35154906T-SIGn tumor reengineering therapy and CAR T cells synergize in combination therapy to clear human lung tumor xenografts and lung metastases in NSG miceOncoimmunology5.333
35465329Digital Spatial Profiling Reveals Functional Shift of Enterochromaffin Cell in Patients With Ulcerative ColitisFront Cell Dev Biol5.206
33584676Next Generation Imaging Techniques to Define Immune Topographies in Solid TumorsFrontiers in Immunology5.085
32328458Changing Technologies of RNA Sequencing and Their Applications in Clinical Oncology Frontiers in oncology4.848
32793500Unraveling the Complexity of the Cancer Microenvironment With Multidimensional Genomic and Cytometric TechnologiesFrontiers in Oncology4.848
33542903Highly Multiplexed Digital Spatial Profiling of the Tumor Microenvironment of Head and Neck Squamous Cell Carcinoma PatientsFrontiers in Oncology4.848
33841448Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When?Front Immunol4.716
35651606Dissecting Tissue Compartment-Specific Protein Signatures in Primary and Metastatic Oropharyngeal Squamous Cell CarcinomasFront Immunol.4.716
35554927Spatial transcriptome of a germinal center plasmablastic burst hints at MYD88/CD79B mutants-enriched diffuse large B-cell lymphomasEur J Immunol4.695
34304051The Pandora’s box of novel technologies that may revolutionize lung cancerLung Cancer4.599
32249818Digital Quantitative Assessment of PD-L1 Using Digital Spatial Profiling Laboratory Investigation4.197
33623115Protein-based immune profiles of basal-like vs. luminal breast cancersLaboratory investigation4.197
The Potential of OMICs Technologies for the Treatment of Immune-Mediated Inflammatory DiseasesInt J Mol Sci4.183
33097816From whole-mount to single-cell spatial assessment of gene expression in 3DCommun Biol4.165
33335270Molecularly targeted photothermal ablation improves tumor specificity and immune modulation in a rat model of hepatocellular carcinomaCommunications Biology4.165
33854972Multiplexed Immunohistochemistry and Digital Pathology as the Foundation for Next-Generation Pathology in Melanoma: Methodological Comparison and Future Clinical Applications.Front Oncol
4.137
34123788Cutaneous Melanoma Classification: The Importance of High-Throughput Genomic TechnologiesFront Oncol
4.137
35083152Spatial Profiling Identifies Prognostic Features of Response to Adjuvant Therapy in Triple Negative Breast Cancer (TNBC)Front Oncol4.137
34838031The tumor immune microenvironment of primary and metastatic HER2- positive breast cancers utilizing gene expression and spatial proteomic profilingJ Transl Med4.098
34838031The tumor immune microenvironment of primary and metastatic HER2- positive breast cancers utilizing gene expression and spatial proteomic profilingJ Transl Med4.098
34561502Dissection of the bone marrow microenvironment in hairy cell leukaemia identifies prognostic tumour and immune related biomarkersSci Rep4.011
32313087Spatially-resolved quantification of proteins in triple negative breast cancers reveals differences in the immune microenvironment associated with prognosis.Scientific Reports 3.998
32339226Cell Atlas technologies and insights into tissue architectureBiochemical Journal3.995
OMICs, Epigenetics, and Genome Editing Techniques for Food and Nutritional SecurityPlants3.935
33005195Identification of Molecular Signatures in Neural Differentiation and Neurological Diseases Using Digital Color-Coded
Molecular Barcoding
Stem Cells International3.869
33611828Single-cell sequencing in translational cancer research and challenges to meet clinical diagnostic needsGenes Chromosomes Cancer
3.836
35672770Digital quantification of p16-positive foci in fibrotic interstitial lung disease is associated with a phenotype of idiopathic pulmonary fibrosis with reduced survivalRespir Res3.829
32765578Unraveling Heterogeneity in Transcriptome and Its Regulation Through Single-Cell Multi-Omics TechnologiesFrontiers in Genetics3.819
34506752Molecular Profiling of Coronavirus Disease 2019 (COVID-19) Autopsies Uncovers Novel Disease MechanismsAm J Pathol3.762
Next-Generation Digital Histopathology of the Tumor MicroenvironmentGenes3.759
34366832Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD StudyFront Aging Neurosci3.633
30038466Multiparametric analysis of colorectal cancer immune responsesWorld J Gastroenterol3.602
34386519Tissue Multiplex Analyte Detection in Anatomic Pathology – Pathways to Clinical ImplementationFront Mol Biosci3.565
34125481Spatial transcriptomics and proteomics technologies for deconvoluting the tumor microenvironmentBiotechnol J3.543
35111697Elucidating Spatially-Resolved Changes in Host Signaling During Plasmodium Liver-Stage InfectionFront Cell Infect Microbiol3.518
Clinical and research applications of multiplexed immunohistochemistry and in situ hybridizationThe Journal of Pathology3.489
34681023High-Dimensional Single-Cell Transcriptomics in Melanoma and Cancer ImmunotherapyGenes (Basel)3.331
32549391Resolving Metabolic Heterogeneity in Experimental Models of the Tumor Microenvironment from a Stable Isotope Resolved Metabolomics Perspectivemetabolites3.303
35428170 Identification and prognostic analysis of biomarkers to predict the progression of pancreatic cancer patientsMol Med2.991
32458049Digital Spatial Profiling Application in Breast Cancer: A User's Perspective Virchows Archiv2.906
34529723Cracking it - successful mRNA extraction for digital gene expression analysis from decalcified, formalin-fixed and paraffin-embedded bone tissuePLoS One2.776
35580406Placental interferon signaling is involved in chronic intervillositis of unknown etiologyPlacenta2.773
34782601From bulk, single-cell to spatial RNA sequencingInt J Oral Sci2.75
31895753Phase Ib/II trial testing combined radiofrequency ablation and ipilimumab in uveal melanoma (SECIRA-UM)Melanoma Research2.381
31079803Future Research Goals in ImmunotherapySurgical Oncology Clinics of North America2.34
33709779Molecular and morphological changes induced by ivosidenib correlate with efficacy in mutant- IDH1 cholangiocarcinomaFuture Oncol2.332
Advanced molecular characterization using Digital Spatial Profiling Technology on immuno-oncology targets in methylated compared with unmethylated IDH-wildtype glioblastoma.Journal of Oncology2.096
33857852Molecular risk markers related to local tumor recurrence at histological margin-free endoscopically resected early gastric cancers: A pilot studyPathol Res Pract2.05
34590593New Insights into the Biology and Diagnosis of Splenic Marginal Zone LymphomasCurr Oncol1.862
33692852Integrin-linked kinase pathway in heterogeneous pulmonary sarcomatoid carcinomaOncology letters0.987
High multiplex, digital spatial profiling of proteins and RNA in fixed tissue using genomic detection methodsbioRxiv
Defining the microenvironment landscape of bladder cancer using highly multiplexed spatial genomic and proteomic analysisbioRxiv
Single-nucleus and spatial transcriptomics of archival pancreatic cancer reveals multi-compartment reprogramming after neoadjuvant treatmentbioRxiv
33083730A Spatially Resolved Dark- versus Light-Zone Microenvironment Signature Subdivides Germinal Center-Related Aggressive B Cell LymphomasiScience
Transcriptome-wide spatial RNA profiling maps the
cellular architecture of the developing human neocortex
bioRxiv
34162701A Distinct Innate Immune Signature of Early Onset Colorectal CancerImmunohorizons
32215866New Technologies to Image TumorsCancer Treat Res
Whole Slide Imaging and Research ApplicationsWhole Slide Imaging
34750164Genome analysis identifies differences in the transcriptional targets of duodenal versus pancreatic neuroendocrine tumoursBMJ Open Gastroenterol
An Investigation of Attention Mechanisms in Histopathology Whole-Slide-Image Analysis for Regression ObjectivesIEEE/CVF
34890147Mixed Effects Machine Learning Models for Colon Cancer Metastasis Prediction using Spatially Localized Immuno-Oncology MarkersPac Symp Biocomput
35580295Protein Profiling of Breast Cancer for Treatment Decision-MakingAm Soc Clin Oncol Educ Book
35751462The Role of Nerve Fibers in the Tumor Immune Microenvironment of Solid TumorsAdv Biol (Weinh)
30613381Dissecting diffuse large B-cell lymphomas of the “not otherwise specified” type: the impact of molecular techniquesF1000research
A user's perspective on GeoMx digital spatial profilingImmuno-Oncology Technology
High multiplex analysis of the immune microenvironment in bone marrow trephine samples using GeoMX™ digital spatial profilingImmuno-Oncology Technology
31502169High-Plex Spatially Resolved RNA and Protein Detection Using Digital Spatial Profiling: A Technology Designed for Immuno-oncology Biomarker Discovery and Translational ResearchBiomarkers for Immunotherapy of Cancer
32394392GeoMx™ RNA Assay: High Multiplex, Digital, Spatial Analysis of RNA in FFPE Tissue Methods in Molecular Biology
31502165Overview of Tissue Imaging Methods.Biomarkers for Immunotherapy of Cancer
Spatially-resolved proteomics and transcriptomics: An emerging digital spatial profiling approach for tumor microenvironmentVisualized Cancer Medicine
35194605A model of persistent post SARS-CoV-2 induced lung disease for target identification and testing of therapeutic strategiesbioRxiv

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