DSP技术服务 – 非因生物

中国第一个DSP空间多组学技术平台

⊕ DSP 数字空间多组学技术服务介绍

⊕ 非因生物DSP工作原理

⊕ 非因生物DSP技术服务内容

DSP 数字空间多组学技术服务介绍

非因生物的Digital Spatial Profiler (DSP) 数字空间多组学分析技术是针对肿瘤免疫和肿瘤微环境高精度、多维度分析的新一代空间组学技术，可以在单张切片上（FFPE 或鲜冻）通过兴趣点选择（ROI），分析每个微环境微小区域内的多达150 重蛋白组或18,000 重全转录组的原位表达谱。

非因生物引入中国第一个DSP 技术平台，率先搭建起国内领先的空间多组学实验室，现拥有3台DSP 仪器同步运行，是目前国内最大的 DSP 技术服务平台，已为数百个项目提供优质的空间多组学服务，包括DSP 空间蛋白组、DSP-CTA 癌症空间转录组、以及DSP-WTA 空间全转录组分析服务。非因生物拥有大量项目开发经验，多仪器高效运行，专业的技术支持和强大的生信分析团队，为您的科研保驾护航。

非因生物DSP工作原理

非因生物DSP 技术服务内容

DSP蛋白靶点查询

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非因生物DSP技术服务的应用场景

非因生物DSP技术服务特点与优势

异质性解析:可通过功能性的区域分割对组织空间异质性进行解析。
更大的检测范围：可对样本进行全转录组或 150 重蛋白組检测，实现最多重、最高灵敏度的检测。
可靠的效果：DSP 具有无与伦比的可重复性和可扩展性，可增加多样本分析和队列研究结果的一致性。

样本将不再受限：从石蜡切片 (FFPE)、冰冻切片（FF)、穿刺活检 (CNB) 以及组织芯片（TMA)均可获得经验证的可靠且稳定的结果。
结构决定功能：全面解析不同区域、不同功能的细胞亚群或关键结构，构建生物学全貌。
强大的数据综合分析及深度挖掘能力：完全标准化的集成生物信息学分析流程，经验丰富的多组学数据分析团队，能够对生物学数据及临床数据进行综合分析及深度挖掘，使得论文发表更加便捷化、个性化。

该场景适用于以下应用方向

蛋白功能分析
细胞信号转导机理研究
疾病模型分子机理挖掘与探索性研究

蛋白功能分析
细胞信号转导机理研究
疾病模型分子机理挖掘与探索性研究

DSP技术平台应用文献总览

DSP技术平台应用代表性文献

参考文献

PMID	文献名	发表期刊	影响因子
31942071	Tertiary lymphoid structures improve immunotherapy and survival in melanoma	Nature	43.07
31942075	B cells and tertiary lymphoid structures promote immunotherapy response	Nature	43.07
33915569	COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets.	Nature	43.07
33780969	The spatial landscape of lung pathology during COVID-19 progression	Nature	42.778
32393914	Multiplex Digital Spatial Profiling of Proteins and RNA in Fixed Tissue	Nature Biotechnology	36.558
34798069	Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb	Cell	36.216
30297909	Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma	Nature Medicine	36.13
30297911	Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma	Nature Medicine	36.13
33495604	Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma	Nat Med	36.13
32976798	Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma	Cell	33.116
34450029	Spatially organized multicellular immune hubs in human colorectal cancer	Cell	33.116
31332390	A case report of clonal EBV-like memory CD4+ T cell activation in fatal checkpoint inhibitor-induced encephalitis	Nature Medicine	30.641
35618839	Pembrolizumab in soft-tissue sarcomas with tertiary lymphoid structures: a phase 2 PEMBROSARC trial cohort	Nat Med	30.641
35589854	Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial	Nat Med	30.641
34341583	Spatial omics and multiplexed imaging to explore cancer biology	Nat Methods	28.467
34479871	Low Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy	Cancer Discov	26.37
34642171	Single-cell atlas of lineage states, tumor microenvironment and subtype-specific expression programs in gastric cancer	Cancer Discov	26.37
34358448	The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer	Cancer Cell	23.916
34678153	Expression of chimeric antigen receptor therapy targets detected by single-cell sequencing of normal cells may contribute to off-tumor toxicity	Cancer Cell	23.916
34966897	Spatial proteomic characterization of HER2-positive breast tumors through neoadjuvant therapy predicts response	Nature Cancer	23.177
31350575	Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer’s disease patient brain samples	Acta Neuropathol	18.174
34376518	Comparison between non-pulmonary and pulmonary immune responses in a HIV decedent who succumbed to COVID-19	Gut	17.943
33205067	Elevated Serum Amino Acids Induce a Subpopulation of Alpha Cells to Initiate Pancreatic Neuroendocrine Tumor Formation	Cell Reports Medicine	16.988
33778787	Spatial mapping of SARS-CoV-2 and H1N1 Lung Injury Identifies Differential Transcriptional Signatures	Cell Reports Medicine	16.988
35233546	System-wide transcriptome damage and tissue identity loss in COVID-19 patients	Cell Rep Med	16.988
32493790	Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia	Science translational medicine	16.89
33563664	Non-genetic evolution drives lung adenocarcinoma spatial heterogeneity and progression	Cancer discovery	15.929
33826920	Applicability of spatial transcriptional profiling to cancer research	Mol Cell	15.584
32375063	Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36	Neuron	14.249
31039798	The tech for the next decade: promises andchallenges in genome biology	Genome Biology	14.028
35490853	Discovery of Biomarkers of Resistance to Immune Checkpoint Blockade in NSCLC Using High-Plex Digital Spatial Profiling	J Thorac Oncol	12.46
33298930	Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection	Nat Commun	12.298
33658518	Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling	Nat Commun	12.298
33712587	Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions	Nat Commun	12.298
34188042	Resolution of tissue signatures of therapy response in patients with recurrent GBM treated with neoadjuvant anti-PD1	Nat Commun	11.878
34162872	Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer	Developmental Therapeutics Branch, Center for Cancer Research	11.878
34285220	High-depth spatial transcriptome analysis by photo-isolation chemistry	Nat Commun	11.878
35046414	Advances in mixed cell deconvolution enable quantification of cell types in spatial transcriptomic data	Nat Commun	11.878
35022412	Postmortem high-dimensional immune profiling of severe COVID-19 patients reveals distinct patterns of immunosuppression and immunoactivation		11.878
35418199	Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer	Nat Commun	11.878
34675048	Profiling of lung SARS-CoV-2 and influenza virus infection dissects virus-specific host responses and gene signatures	Eur Respir J	11.807
34271973	Single-cell and spatial analyses of cancer cells: toward elucidating the molecular mechanisms of clonal evolution and drug resistance acquisition	Inflamm Regen	10.426
33262254	Comprehensive analysis of cutaneous and uveal melanoma liver metastases.	J Immunother Cancer	10.252
29784033	AGBT meeting report	Genome Biol.	10.124
32253229	Biomarkers Associated With Beneficial PD-1 Checkpoint Blockade in Non-Small Cell Lung Cancer (NSCLC) Identified Using High-Plex Digital Spatial Profiling	Clinical Cancer Research	10.107
32299817	Multiplexed Evaluation of Microdosed Antineoplastic Agents In Situ in the Tumor Microenvironment of Patients With Soft Tissue Sarcoma	Clinical Cancer Research	10.107
32377572	Multiplex bioimaging of single-cell spatial profiles for precision cancer diagnostics and therapeutics	Npj Precision Oncology	10.092
34050252	Models that combine transcriptomic with spatial protein information exceed the predictive value for either single modality	NPJ Precis Oncol	10.092
34667258	Multiomics analysis of serial PARP inhibitor treated metastatic TNBC inform on rational combination therapies	NPJ Precis Oncol	10.092
32414858	The Society for Immunotherapy of Cancer statement on best practices for multiplex immunohistochemistry (IHC) and immunofluorescence (IF) staining and validation.	Journal for ImmunoTherapy of Cancer	9.913
35508175	ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancer	Dev Cell	9.19
29903534	Harnessing tumor evolution to circumvent resistance	Trends Genet.	9.012
31189645	High-plex predictive marker discovery for melanoma immunotherapy treated patients using Digital Spatial Profiling	Clinical Cancer Research	8.911
31948941	Linking transcriptomic and imaging data defines features of a favorable tumor immune microenvironment (TIME) and identifies a combination biomarker for primary melanoma	Cancer Research	8.911
33257424	Early Adaptation of Colorectal Cancer Cells to the Peritoneal Cavity Is Associated with Activation of "Stemness" Programs and Local Inflammation	Clin Cancer Res	8.911
34465600	Alpha-smooth muscle actin expression in the stroma predicts resistance to trastuzumab in patients with early-stage HER2-positive breast cancer	Clin Cancer Res	8.911
35031546	Metabolic Alterations and WNT Signaling Impact Immune Response in HGSOC	Clin Cancer Res .	8.911
35262677	Immunostimulatory Cancer-Associated Fibroblast Subpopulations Can Predict Immunotherapy Response in Head and Neck Cancer	Clin Cancer Res	8.911
35617517	Spatial and Transcriptomic Analysis of Perineural Invasion in Oral Cancer	Clin Cancer Res	8.911
35511927	CXCL14 Promotes a Robust Brain Tumor-Associated Immune Response in Glioma	Clin Cancer Res	8.911
35527216	Spatial determinants of CD8 + T cell differentiation in cancer	Trends Cancer	8.884
35378331	The Host-Microbiome Response to Hyperbaric Oxygen Therapy in Ulcerative Colitis Patients	Cell Mol Gastroenterol Hepatol	8.797
31703602	Distinct tumor microenvironments of lytic and blastic bone metastases in prostate cancer patients	Journal for ImmunoTherapy of Cancer	8.676
32581061	High Dose-Rate Brachytherapy of Localized Prostate Cancer Converts Tumors From Cold to Hot	Journal for ImmunoTherapy of Cancer	8.676
34725212	Synergistic antitumor activity of pan-PI3K inhibition and immune checkpoint blockade in bladder cancer	J Immunother Cancer	8.676
35264439	Spatial profiling reveals association between WNT pathway activation and T-cell exclusion in acquired resistance of synovial sarcoma to NY-ESO-1 transgenic T-cell therapy	J Immunother Cancer	8.676
35618288	Spatial transcriptomics of macrophage infiltration in non-small cell lung cancer reveals determinants of sensitivity and resistance to anti-PD1/PD-L1 antibodies	J Immunother Cancer	8.676
34341074	Predicting molecular phenotypes from histopathology images: a transcriptome-wide expression-morphology analysis in breast cancer	Cancer Res	8.378
34555393	The spatially resolved transcriptional profile of acute T-cell mediated rejection in a kidney allograft	Kidney Int	8.306
35227689	Digital Spatial Profiling of Collapsing Glomerulopathy	Kidney Int	8.306
35461615	Virus-related collapsing glomerulopathy, a common mechanism of injury?	Kidney Int	8.306
34928497	5-alpha reductase inhibitors induce a prostate luminal to club cell transition in human benign prostatic hyperplasia	The Journal of pathology	7.996
34818552	Immuno-transcriptomic profiling of extracranial pediatric solid malignancies	Cell Rep	7.815
35740993	Lung Spatial Profiling Reveals a T Cell Signature in COPD Patients with Fatal SARS-CoV-2 Infection	Cells	7.666
32267932	LAG3: A novel immune checkpoint expressed by multiple lymphocyte subsets in diffuse large B-cell lymphoma	Blood Advances	7.637
35164877	Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling	Acta Neuropathol Commun	7.578
35309370	Digital Spatial Profiling of Individual Glomeruli From Patients With Anti-Neutrophil Cytoplasmic Autoantibody-Associated Glomerulonephritis	Front Immunol	7.561
34406120	Innate immune activation by checkpoint inhibition in human patient-derived lung cancer tissues	Elife	7.551
31432604	Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease	Aging Cell	7.238
34726836	Novel intragraft regulatory lymphoid structures in kidney allograft tolerance	Am J Transplant	7.163
34820878	Spatial molecular profiling of a central nervous system low-grade diffusely infiltrative tumour with INI1 deficiency (CNS LGDIT-INI1) featuring a high-grade AT/RT component	Neuropathol Appl Neurobiol	6.878
34673228	High-plex expression profiling reveals that implants drive spatiotemporal protein production and innate immune activation for tissue repair	Acta Biomater	6.638
35091681	Loss of NFE2L3 protects against inflammation-induced colorectal cancer through modulation of the tumor microenvironment	Oncogene	6.634
33402537	Hyaluronidase Impairs Neutrophil Function and Promotes Group B Streptococcus Invasion and Preterm Labor in Nonhuman Primates	mBio	6.63
33348809	Murine-and Human-Derived Autologous Organoid/Immune Cell Co-Cultures as Pre-Clinical Models of Pancreatic Ductal Adenocarcinoma	Cancers (Basel)	6.575
34944780	Disruption of Her2-Induced PD-L1 Inhibits Tumor Cell Immune Evasion in Patient-Derived Gastric Cancer Organoids	Cancers (Basel)	6.575
35158790	NanoString Digital Molecular Profiling of Protein and microRNA in Rhabdomyosarcoma	Cancers (Basel)	6.575
35454904	Dissecting Tumor-Immune Microenvironment in Breast Cancer at a Spatial and Multiplex Resolution	Cancers (Basel)	6.575
35454766	Cutting-Edge Platforms for Analysis of Immune Cells in the Hepatic Microenvironment—Focus on Tumor-Associated Macrophages in Hepatocellular Carcinoma	Cancers (Basel)	6.575
	Mapping Gene Expression in the Spatial Dimension	Neuroimage	6.552
34126195	Hedgehog transcriptional effector GLI mediates mTOR-Induced PD-L1 expression in gastric cancer organoids	Cancer Lett	6.508
33072322	Immune contexture analysis in immuno‐oncology: applications and challenges of multiplex fluorescent immunohistochemistry	Clin Transl Immunology.	6.484
31654804	Identification of non-cancer cells from cancer transcriptomic data	Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms	6.304
34699906	High-plex spatial RNA profiling reveals cell type-specific biomarker expression during melanoma development	J Invest Dermatol	6.29
31672982	Single cell analysis to dissect molecular heterogeneity and disease evolution in metastatic melanoma	Cell Death Dis.	6.28
33261133	High-Plex and High-Throughput Digital Spatial Profiling of Non-Small-Cell Lung Cancer (NSCLC)	Cancers	6.126
33228231	Immunoprofiling in Neuroendocrine Neoplasms Unveil Immunosuppressive Microenvironment	Cancers	6.126
	A High-Dimensional Window into the Micro-Environment of Triple Negative Breast Cancer	Cancers	6.126
34503266	Best Practices for Spatial Profiling for Breast Cancer Research with the GeoMx® Digital Spatial Profiler	Cancers	6.126
34778231	Tumor Microenvironment Profiles Reveal Distinct Therapy-Oriented Proteogenomic Characteristics in Colorectal Cancer	Front Bioeng Biotechnol	6.064
31830001	Immunologic alterations in the pancreatic cancer microenvironment of patients treated with neoadjuvant chemotherapy and radiotherapy	JCI Insight	6.014
31960425	Loss of BAP1 expression is associated with an immunosuppressive microenvironment in uveal melanoma, with implications for immunotherapy development.	J Pathol	5.979
34018684	Multiplexed digital spatial profiling of invasive breast tumors from Black and White women.	Mol Oncol	5.962
30570141	New tools for pathology: a user's review of a highly multiplexed method for in situ analysis of protein and RNA expression in tissue	Journal of Pathology	5.942
34580877	Stroma Areactive Invasion Front Areas (SARIFA) - a new prognostic biomarker in gastric cancer related to tumor-promoting adipocytes	J Pathol	5.942
35365599	Clinical and translational values of spatial transcriptomics	Signal Transduct Target Ther	5.873
32751181	Personal Medicine and Bone Metastases: Biomarkers, Micro-RNAs and Bone Metastases	Cancers	5.744
32917035	Transcriptional Spatial Profiling of Cancer Tissues in the Era of Immunotherapy: The Potential and Promise	Cancers	5.744
33096480	Intra-tumour heterogeneity of diffuse large B-cell lymphoma involves the induction of diversified stroma-tumour interfaces	EBioMedicine	5.736
33434721	Spatially resolved transcriptomics and its applications in cancer	Current Opinion in Genetics & Development	5.517
35063125	The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2	Stem Cell Reports	5.499
32814992	Dissecting the immune landscape of tumor draining lymph nodes in melanoma with high-plex spatially resolved protein detection	Cancer Immunology, Immunotherapy	5.442
35154906	T-SIGn tumor reengineering therapy and CAR T cells synergize in combination therapy to clear human lung tumor xenografts and lung metastases in NSG mice	Oncoimmunology	5.333
35465329	Digital Spatial Profiling Reveals Functional Shift of Enterochromaffin Cell in Patients With Ulcerative Colitis	Front Cell Dev Biol	5.206
33584676	Next Generation Imaging Techniques to Define Immune Topographies in Solid Tumors	Frontiers in Immunology	5.085
32328458	Changing Technologies of RNA Sequencing and Their Applications in Clinical Oncology	Frontiers in oncology	4.848
32793500	Unraveling the Complexity of the Cancer Microenvironment With Multidimensional Genomic and Cytometric Technologies	Frontiers in Oncology	4.848
33542903	Highly Multiplexed Digital Spatial Profiling of the Tumor Microenvironment of Head and Neck Squamous Cell Carcinoma Patients	Frontiers in Oncology	4.848
33841448	Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When?	Front Immunol	4.716
35651606	Dissecting Tissue Compartment-Specific Protein Signatures in Primary and Metastatic Oropharyngeal Squamous Cell Carcinomas	Front Immunol.	4.716
35554927	Spatial transcriptome of a germinal center plasmablastic burst hints at MYD88/CD79B mutants-enriched diffuse large B-cell lymphomas	Eur J Immunol	4.695
34304051	The Pandora’s box of novel technologies that may revolutionize lung cancer	Lung Cancer	4.599
32249818	Digital Quantitative Assessment of PD-L1 Using Digital Spatial Profiling	Laboratory Investigation	4.197
33623115	Protein-based immune profiles of basal-like vs. luminal breast cancers	Laboratory investigation	4.197
	The Potential of OMICs Technologies for the Treatment of Immune-Mediated Inflammatory Diseases	Int J Mol Sci	4.183
33097816	From whole-mount to single-cell spatial assessment of gene expression in 3D	Commun Biol	4.165
33335270	Molecularly targeted photothermal ablation improves tumor specificity and immune modulation in a rat model of hepatocellular carcinoma	Communications Biology	4.165
33854972	Multiplexed Immunohistochemistry and Digital Pathology as the Foundation for Next-Generation Pathology in Melanoma: Methodological Comparison and Future Clinical Applications.	Front Oncol	4.137
34123788	Cutaneous Melanoma Classification: The Importance of High-Throughput Genomic Technologies	Front Oncol	4.137
35083152	Spatial Profiling Identifies Prognostic Features of Response to Adjuvant Therapy in Triple Negative Breast Cancer (TNBC)	Front Oncol	4.137
34838031	The tumor immune microenvironment of primary and metastatic HER2- positive breast cancers utilizing gene expression and spatial proteomic profiling	J Transl Med	4.098
34838031	The tumor immune microenvironment of primary and metastatic HER2- positive breast cancers utilizing gene expression and spatial proteomic profiling	J Transl Med	4.098
34561502	Dissection of the bone marrow microenvironment in hairy cell leukaemia identifies prognostic tumour and immune related biomarkers	Sci Rep	4.011
32313087	Spatially-resolved quantification of proteins in triple negative breast cancers reveals differences in the immune microenvironment associated with prognosis.	Scientific Reports	3.998
32339226	Cell Atlas technologies and insights into tissue architecture	Biochemical Journal	3.995
	OMICs, Epigenetics, and Genome Editing Techniques for Food and Nutritional Security	Plants	3.935
33005195	Identification of Molecular Signatures in Neural Differentiation and Neurological Diseases Using Digital Color-Coded Molecular Barcoding	Stem Cells International	3.869
33611828	Single-cell sequencing in translational cancer research and challenges to meet clinical diagnostic needs	Genes Chromosomes Cancer	3.836
35672770	Digital quantification of p16-positive foci in fibrotic interstitial lung disease is associated with a phenotype of idiopathic pulmonary fibrosis with reduced survival	Respir Res	3.829
32765578	Unraveling Heterogeneity in Transcriptome and Its Regulation Through Single-Cell Multi-Omics Technologies	Frontiers in Genetics	3.819
34506752	Molecular Profiling of Coronavirus Disease 2019 (COVID-19) Autopsies Uncovers Novel Disease Mechanisms	Am J Pathol	3.762
	Next-Generation Digital Histopathology of the Tumor Microenvironment	Genes	3.759
34366832	Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study	Front Aging Neurosci	3.633
30038466	Multiparametric analysis of colorectal cancer immune responses	World J Gastroenterol	3.602
34386519	Tissue Multiplex Analyte Detection in Anatomic Pathology – Pathways to Clinical Implementation	Front Mol Biosci	3.565
34125481	Spatial transcriptomics and proteomics technologies for deconvoluting the tumor microenvironment	Biotechnol J	3.543
35111697	Elucidating Spatially-Resolved Changes in Host Signaling During Plasmodium Liver-Stage Infection	Front Cell Infect Microbiol	3.518
	Clinical and research applications of multiplexed immunohistochemistry and in situ hybridization	The Journal of Pathology	3.489
34681023	High-Dimensional Single-Cell Transcriptomics in Melanoma and Cancer Immunotherapy	Genes (Basel)	3.331
32549391	Resolving Metabolic Heterogeneity in Experimental Models of the Tumor Microenvironment from a Stable Isotope Resolved Metabolomics Perspective	metabolites	3.303
35428170	Identification and prognostic analysis of biomarkers to predict the progression of pancreatic cancer patients	Mol Med	2.991
32458049	Digital Spatial Profiling Application in Breast Cancer: A User's Perspective	Virchows Archiv	2.906
34529723	Cracking it - successful mRNA extraction for digital gene expression analysis from decalcified, formalin-fixed and paraffin-embedded bone tissue	PLoS One	2.776
35580406	Placental interferon signaling is involved in chronic intervillositis of unknown etiology	Placenta	2.773
34782601	From bulk, single-cell to spatial RNA sequencing	Int J Oral Sci	2.75
31895753	Phase Ib/II trial testing combined radiofrequency ablation and ipilimumab in uveal melanoma (SECIRA-UM)	Melanoma Research	2.381
31079803	Future Research Goals in Immunotherapy	Surgical Oncology Clinics of North America	2.34
33709779	Molecular and morphological changes induced by ivosidenib correlate with efficacy in mutant- IDH1 cholangiocarcinoma	Future Oncol	2.332
	Advanced molecular characterization using Digital Spatial Profiling Technology on immuno-oncology targets in methylated compared with unmethylated IDH-wildtype glioblastoma.	Journal of Oncology	2.096
33857852	Molecular risk markers related to local tumor recurrence at histological margin-free endoscopically resected early gastric cancers: A pilot study	Pathol Res Pract	2.05
34590593	New Insights into the Biology and Diagnosis of Splenic Marginal Zone Lymphomas	Curr Oncol	1.862
33692852	Integrin-linked kinase pathway in heterogeneous pulmonary sarcomatoid carcinoma	Oncology letters	0.987
	High multiplex, digital spatial profiling of proteins and RNA in fixed tissue using genomic detection methods	bioRxiv
	Defining the microenvironment landscape of bladder cancer using highly multiplexed spatial genomic and proteomic analysis	bioRxiv
	Single-nucleus and spatial transcriptomics of archival pancreatic cancer reveals multi-compartment reprogramming after neoadjuvant treatment	bioRxiv
33083730	A Spatially Resolved Dark- versus Light-Zone Microenvironment Signature Subdivides Germinal Center-Related Aggressive B Cell Lymphomas	iScience
	Transcriptome-wide spatial RNA profiling maps the cellular architecture of the developing human neocortex	bioRxiv
34162701	A Distinct Innate Immune Signature of Early Onset Colorectal Cancer	Immunohorizons
32215866	New Technologies to Image Tumors	Cancer Treat Res
	Whole Slide Imaging and Research Applications	Whole Slide Imaging
34750164	Genome analysis identifies differences in the transcriptional targets of duodenal versus pancreatic neuroendocrine tumours	BMJ Open Gastroenterol
	An Investigation of Attention Mechanisms in Histopathology Whole-Slide-Image Analysis for Regression Objectives	IEEE/CVF
34890147	Mixed Effects Machine Learning Models for Colon Cancer Metastasis Prediction using Spatially Localized Immuno-Oncology Markers	Pac Symp Biocomput
35580295	Protein Profiling of Breast Cancer for Treatment Decision-Making	Am Soc Clin Oncol Educ Book
35751462	The Role of Nerve Fibers in the Tumor Immune Microenvironment of Solid Tumors	Adv Biol (Weinh)
30613381	Dissecting diffuse large B-cell lymphomas of the “not otherwise specified” type: the impact of molecular techniques	F1000research
	A user's perspective on GeoMx digital spatial profiling	Immuno-Oncology Technology
	High multiplex analysis of the immune microenvironment in bone marrow trephine samples using GeoMX™ digital spatial profiling	Immuno-Oncology Technology
31502169	High-Plex Spatially Resolved RNA and Protein Detection Using Digital Spatial Profiling: A Technology Designed for Immuno-oncology Biomarker Discovery and Translational Research	Biomarkers for Immunotherapy of Cancer
32394392	GeoMx™ RNA Assay: High Multiplex, Digital, Spatial Analysis of RNA in FFPE Tissue	Methods in Molecular Biology
31502165	Overview of Tissue Imaging Methods.	Biomarkers for Immunotherapy of Cancer
	Spatially-resolved proteomics and transcriptomics: An emerging digital spatial profiling approach for tumor microenvironment	Visualized Cancer Medicine
35194605	A model of persistent post SARS-CoV-2 induced lung disease for target identification and testing of therapeutic strategies	bioRxiv